(Original PDF) An Introduction to Medicinal Chemistry 6th by Graham Patrick – Digital Ebook – Instant Delivery Download
Product details:
- ISBN-10 : 9780198749691
- ISBN-13 : 978-0198749691
- Author: Graham Patrick (Author)
An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.
Table contents:
1:Drugs and Drug Targets
2:Protein Structure and Function
3:Enzymes: Structure and Function
4:Receptors: Structure and Function
5:Receptors and Signal Transduction
6:Nucleic Acids: Structure and Function
7:Enzymes as Drug Targets
8:Receptors as Drug Targets
9:Nucleic Acids as Drug Targets
10:Miscellaneous Drug Targets
11:Pharmacokinetics and Related Topics
Case Study 1:Statins
12:Drug Discovery: Finding a Lead
13:Drug Design: Optimizing Target Interactions
14:Drug Design: Optimizing Access to the Target
15:Getting the Drug to Market
Case Study 2:The Design of ACE Inhibitors
Case Study 3:Artemisinin and Related Antimalarial Drugs
Case Study 4:The Design of Oxamni
Case Study 5:Fosfidomycin as an Antimalarial Agent
16:Combinatorial and Parallel Synthesis
17:In Silico Drug Design
18:Quantitative Structure-Activity Relationships
Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor
19:Antibacterial Agents
20:Antiviral Agents
21:Anticancer Agents
22:Protein Kinase Inhibitors as Anticancer Agents
23:Antibodies and Other Biologics
24:Cholinergics, Anticholinergics, and Anticholinestarases
25:Drugs Acting on the Adrenergic Nervous System
26:The Opioid Analgesics
27:Anti-Ulcer Agents
28:Cardiovascular Drugs
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