Macrophages in the Human Body : A Tissue Level Approach 1st edition – Ebook PDF Instant Delivery – ISBN(s): 9780128213858,012821385X,9780128213865, 0128213868
Product details:
- ISBN-10 : 0128213868
- ISBN-13 : 9780128213865
- Author: Niels Olson Saraiva Camara, Tárcio Teodoro Braga
Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.
Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.
Table of contents:
Chapter 1: Macrophages: From Metchnikoff to 2020 and ahead
Chapter 2: Macrophage differentiation
Chapter 3: Metabolic requirement for macrophages
Chapter 4: Spleen, lymph nodes, and lymphoid tissues—Inflammatory system
Chapter 5: Kidney—Inflammation and remodeling
Chapter 6: Dermal macrophages in health and disease
Chapter 7: Bone—From macrophage to osteoclast and osteolytic diseases
Chapter 8: Microglia and border-associated macrophages in the central nervous system
Chapter 9: Intestines—Inflammatory and digestive system
Chapter 10: Lungs—Inflammatory and respiratory system
Chapter 11: Macrophages in the immune-endocrine milieu of reproductive tissues
Chapter 12: Macrophages at the maternal-fetal interface
Chapter 13: Targeting macrophages in systemic diseases
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