(eBook PDF) Science of Synthesis: Flow Chemistry in Organic Synthesis

(eBook PDF) Science of Synthesis: Flow Chemistry in Organic Synthesis – Digital Ebook – Instant Delivery Download

product details:

• ISBN-10 ‏ : ‎ 3132423327
• ISBN-13 ‏ : ‎ 978-3132423329
• Author: Timothy Jamison, Guido Koch 

The aim of this work is to convey the practice, power, and potential of flow chemistry to a larger audience. An emerging and strengthening trend is that flow chemistry is much more than the adaption of batch processes to flow systems. Rather, flow chemistry offers a new paradigm in the way we think about chemical synthesis. This volume demonstrates the enabling power of continuous flow to access new reaction types and different chemistry space and, to this end, it has been compiled by a team of pioneers and leaders, who present both the practical and conceptual aspects of this rapidly growing field. Included are the principles of reactor design, automation, and separations/purifications in flow systems, applications in photochemistry, electrochemistry, gaseous systems, immobilized reagents and catalysts, and multistep processes. The synthesis of peptides, carbohydrates, and pharmaceuticals is covered and several chapters give insight into the use of flow in an industrial context.

table of contents:

1 Retrosynthesis, Stereochemistry, And Conformations

2 Acids And Bases and Addition Reactions

3 Functional Group Exchange Reactions.   Aliphatic and Aromatic Substitution,   and Elimination Reactions

4 Acids, Bases, And Functional Group Exchange Reactions.   Acyl Addition and Acyl Substitution

5 Functional Groups Exchange Reactions.    Protecting Groups

6 Functional Group Exchange Reactions. Oxidations

7 Functional Group Exchange Reactions. Reductions

8 SYNTHETIC STRATEGIES

9 Functional Group Exchange Reactions.  Hydroboration

10 Functional Group Exchange Reactions.   Selectivity

11 Carbon-Carbon Bond-Forming Reactions.   Cyanide, Alkyne Anions, Grignard Reagents, and Organolithium Reagents

12 Carbon–Carbon Bond-Forming Reactions.   Stabilized Carbanions, Organocuprates, and Ylids

13 Carbon-Carbon Bond-Forming Reactions.   Enolate Anions

14 Pericyclic Reactions.  The Diels–Alder Reaction

15 Pericyclic Reactions: [m+n]-Cycloadditions, Sigmatropic Rearrangements,   Electrocyclic and Ene Reactions

16 Carbon-Carbon Bond-Forming Reactions.   Carbocation and Oxocarbenium Ion Intermediates

17 Formation Of Carbon-Carbon Bonds Via Radicals and Carbenes

18 Metal-Mediated, Carbon-Carbon Bond-Forming Reactions

19 Combinatorial And Process Chemistry

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