(eBook PDF) Cell Signaling: principles and mechanisms

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product details:

• ISBN-10 ‏ : ‎ 0815342446
• ISBN-13 ‏ : ‎ 978-0815342441
• Author: Wendell Lim, Bruce Mayer, Tony Pawson

Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and provide a comprehensive overview of major eukaryotic signaling pathways.

table of contents:

1.Overview of Signal Transduction
2.Principles and Mechanisms of Protein Interactions
3.Signaling Enzymes and Their Allosteric Regulation
4.Role of Post-Translational Modifications in Signaling
5.Subcellular Localization of Signaling Molecules
6.Small Soluble Signaling Mediators
7.Lipids and Enzymes that Modify Them
8.Information Transfer Across the Membrane
9.Regulated Protein Degradation
10.Modular Architecture and Evolution of Signaling Proteins
11.Signaling Devices in Networks
12.How Cells Make Decisions
13.Methods for Studying Signaling Proteins and Networks

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