Biophysical characterization of proteins in developing biopharmaceuticals – Ebook PDF Instant Delivery – ISBN(s): 9780444641748,0444641742
Product details:
- ISBN-10 : 0444638105
- ISBN-13 : 978-0444638106
- Author: Damian J. Houde,
Biophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly employed in the biopharmaceutical industry today as well as up and coming promising methods that are now gaining increasing attention.
As a general resource guide this book has been written with the intent to help today’s industrial scientists working in the biopharmaceutical industry or the scientists of tomorrow who are planning a career in this industry on how to successfully implement these biophysical methodologies. In so doing a keen focus is placed on understanding the capability of these methodologies in terms of what information they can deliver. Aspects of how to best acquire this biophysical information on these very complex drug molecules, while avoiding potential pitfalls, in order to make concise, well informed productive decisions about their development are key points that are also covered.
Table of contents:
Chapter 1. The Complexity of Protein Structure and the Challenges it Poses in Developing Biopharmaceuticals
Chapter 2. Biophysical Characterization and Its Role in the Biopharmaceutical Industry
Chapter 3. Biopharmaceutical Industry’s Biophysical Toolbox
Chapter 4. An Introduction and Hierarchical Organization of the Biophysical Tool in Section II
Chapter 5. The Value of UV, Fluorescence, and FTIR Spectroscopy in Biopharmaceutical Development
Chapter 6. Circular Dichroism Spectroscopy for Protein Characterization: Biopharmaceutical
Chapter 7. Size-Exclusion Chromatograph (SEC) in Biopharmaceutical Process Development
Chapter 8. Scattering Techniques for the Characterization of Biopharmaceuticals
Chapter 9. Characterizing Biopharmaceuticals using Analytical Ultracentrifugation
Chapter 10. Subvisible and Visible Particle Analysis in Biopharmaceutical Research and Development
Chapter 11. Differential Scanning Calorimetry in the Biopharmaceutical Sciences
Chapter 12. Biophysical Mass Spectrometry for Biopharmaceutical Process Development: Focus on Hydrogen/Deuterium Exchange
Chapter 13. One- and Two-Dimensional NMR Techniques for Biopharmaceuticals
Chapter 14. Biophysical Characterization: An Integral Part of the “Totality of the Evidence” Concept
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