A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery – Ebook PDF Instant Delivery – ISBN(s): 9780128139578,0128139579

Product details:

• ISBN-10 ‏ : ‎ 0128139579
• ISBN-13 ‏ : ‎ 978-0128139578
• Author:  Terry P Kenakin

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more.

Table contents:

Chapter 1 – What is Pharmacology?

Chapter 2 – How Different Tissues Process Drug Response

Chapter 3 – Drug–Receptor Theory

Chapter 4 – Pharmacological Assay Formats: Binding

Chapter 5 – Agonists: The Measurement of Affinity and Efficacy in Functional Assays

Chapter 6 – Orthosteric Drug Antagonism

Chapter 7 – Allosteric Modulation

Chapter 8 – The Optimal Design of Pharmacological Experiments

Chapter 9 – Pharmacokinetics

Chapter 10 – Safety Pharmacology

Chapter 11 – The Drug Discovery Process

Chapter 12 – Statistics and Experimental Design

Chapter 13 – Selected Pharmacological Methods

Chapter 14 – Exercises in Pharmacodynamics and Pharmacokinetics

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