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Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 1st Edition Hiroshi Yamazaki – eBook PDF

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Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary – Ebook PDF

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Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary – Ebook PDF Instant Delivery – ISBN(s): 9780323911092,0323911099

Product details:

  • ISBN-10 ‏ : ‎ 0323911099
  • ISBN-13 ‏ : ‎ 978-0323911092
  • Author: Hiroshi Yamazaki

Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more.

 

Table contents:

Chapter One: Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
Chapter Two: Pharmacogenetics of the cytochromes P450: Selected pharmacological and toxicological aspects
Chapter Three: Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain
Chapter Four: Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences
Chapter Five: Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology
Chapter Six: Biosynthesis using cytochrome P450 enzymes: Focus on synthesis of drug metabolites
Chapter Seven: Use of engineered cytochromes P450 for accelerating drug discovery and development
Chapter Eight: Assessing cytochrome P450 function using genetically engineered mouse models
Chapter Nine: Expression and functional activity of cytochrome P450 enzymes in human hepatocytes with sustainable reproducibility for in vitro phenotyping studies
Chapter Ten: Cytochrome P450s in chimeric mice with humanized liver
Chapter Eleven: Polymorphic cytochromes P450 in non-human primates
Chapter Twelve: Cytochrome P450 enzymes in the pediatric population: Connecting knowledge on P450 expression with pediatric pharmacokinetics
Chapter Thirteen: Cytochrome P450 polymorphism: From evolution to clinical use

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