Cholesterol: From Chemistry and Biophysics to the Clinic – Ebook PDF Instant Delivery – ISBN(s): 9780323858571,0323858570
Product details:
- ISBN-10 : 0323858570
- ISBN-13 : 978-0323858571
- Author: Anna N. Bukiya, Alex M. Dopico
With Cholesterol, Drs. Anna Bukiya and Alex Dopico have compiled a comprehensive resource on biological and clinical aspects of cholesterol, spanning biophysics and biochemistry, as well as the latest pharmacological discoveries employed to tackle disorders associated with abnormal cholesterol levels. Early chapters on basic biology offer guidance in cholesterol lab chemistry, cholesterol metabolism and synthesis, molecular evolution of cholesterol and sterols, cholesterol peptides, and cholesterol modulation. Chapters on cellular and organismal development discuss cholesterol transport in blood, lipoproteins, and cholesterol metabolism; cholesterol detection in the blood; cellular cholesterol levels; hypercholesterolemia; and the role of cholesterol in early human development. Pathophysical specialists consider familial hypobetalipoproteinemia, critical illness and cholesterol levels, coronary artery disease, CESD, cholesterol and viral pathology, cholesterol and neurodegenerative disorders, and cholesterol and substance use disorders. A final section examines pharmacology of drug delivery systems targeting cholesterol related disorders, cholesterol receptors, cholesterol reduction, statins, citrate lyase, cyclodextrins, and clinical management.
Table of contents:
Section 1: Cholesterol chemistry and cell function
Chapter 1: Cholesterol chemistry and laboratory synthesis
Chapter 2: Molecular evolution of cholesterol and other higher sterols in relation to membrane structure
Chapter 3: Role of cholesterol in maintaining the physical properties of the plasma membrane
Chapter 4: The fundamental interaction of cholesterol with lipid membranes: The umbrella model
Chapter 5: Model peptides and cholesterol
Chapter 6: Cholesterol and ceramide: An unlikely pair
Chapter 7: Cholesterol-recognizing amino acid consensus motifs in transmembrane proteins: Comparative analysis of in silico studies and structural data
Chapter 8: Effects of cholesterol on the GPCR AT1 receptor and its interplay with AT1 antagonists
Chapter 9: Principles of cholesterol regulation of ion channels
Chapter 10: Fluorescent probes for microscopy visualization of cholesterol topography and dynamics in membranes
Chapter 11: Cholesterol transport in blood, lipoproteins, and cholesterol metabolism
Chapter 12: Common laboratory research methods for detection and quantification of cholesterol
Chapter 13: Approaches for modifying cellular cholesterol levels and their application to mechanistic studies: Examples from the ion channel field
Section 2: Cholesterol homeostasis and its disruption
Chapter 14: Diet-induced hypercholesterolemia in small laboratory animal models
Chapter 15: Nutrition and cholesterol metabolism
Chapter 16: Cholesterol and early development
Chapter 17: Clinical and biochemical diagnostic methods: What do blood lipid levels tell us?
Chapter 18: Familial hypobetalipoproteinemia and abetalipoproteinemia
Chapter 19: Critical illness and cholesterol levels
Chapter 20: Familial hypercholesterolemia
People also search:
cholesterol: from chemistry and biophysics to the clinic
are cholesterol hydrophobic or hydrophilic
is cholesterol a chemical
is cholesterol a biomolecule
can cholesterol be metabolized for energy