(eBook PDF) Chronic Liver Disease From Molecular Biology to Therapy – Digital Ebook – Instant Delivery Download

Product details:

• ISBN-10 ‏ : ‎ 1536102377
• ISBN-13 ‏ : ‎ 978-1536102376
• Author: R. Schmid, L. Bianchi, H.E. Blum, W. Gerok, K.P. Maier

Chronic liver disease is one of the most prevalent diseases in the developed world. The large amount of new knowledge has resulted in subspecialities, even in issues such as hepatology. Thus every day, it is more difficult to access all relevant information that is being published. Additionally, biomolecular techniques lead to a level of complexity that is only beneficial when dealt with by professionals. This book attempts to give a broad overview of the molecular biology of the liver, emphasizing how this knowledge is the basis of further treatment. Thus, pathophysiology and therapies are updated in viral hepatitis, hepatic encephalopathy and portal hypertension, among others. However, appended issues that apparently are less relevant such as the stem cell and endocannabinoids are included. These two issues will soon be of importance due to their close relationship with the liver tissue and especially with liver disease. There are also new paradigms such as cell death and the implication of the extracellular matrix, which are also addressed. In addition, important issues such as the stellate cells and their intimate relationship with fibrogenesis are treated in-depth. Also the fundamental role of endothelin in chronic liver disease is examined. Because of its prevalence, NASH was discussed with special interest, with a focus on the process from fatty liver to molecular biology of liver cells and metabolism in chronic liver disease. The authors believe that this is a broad vision that describes the basic pathophysiological mechanisms shared by many liver diseases, giving rational support for specific therapies.
Table contents:

1. Hepatitis A and E: Molecular Biology; R.H. Purcell, S.U. Emerson.

2. Hepatitis B Viral Variants; J.R. Wands, et al.

3. The Natural History of Chronic Viral Hepatitis Type B and D; M. Rizzetto.

4. Hepatitis C Virus: Molecular Biology and Genetic Variability; C. Brechot.

5. Hepatitis C: Epidemiology and Clinical Course; H.J. Alter.

6. Hepatitis C: Diagnosis and Therapy; A. Alberti, et al.

Section II: Biliary Liver Diseases.

7. Molecular Pathogenesis of Cholestasis; J.L. Boyer.

8. Biliary Liver Diseases: Diagnosis, Natural Course and Therapy; G. Paumgartner, U. Beuers.

Section III: Toxic Liver Diseases.

9. Pathogenesis and Natural Course of Alcoholic Liver Disease; C.S. Lieber.

10. Therapy of Alcoholic Liver Disease; C. Oneta, et al.

11. Importance of Drug Metabolism for Drug Toxicity; U.A. Meyer.

12. Drug-Induced Hepatotoxicity: Clinical Presentation, Pathogenesis, Risk Factors, Diagnosis and Treatment; S. Krahenbuhl, N. Kaplowitz. Section IV: Metabolic Liver Diseases.

13. Molecular Pathogenesis of Hemochromatosis; C. Camaschella, et al.

14. Hemochromatosis – Recent Diagnostic and Therapeutic Aspects; P. Brissot, et al.
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